| Entry | Database: PDB / ID: 7tta | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Title | P450 (OxyA) from kistamicin biosynthesis, mixed heme conformation, attenuated beam | ||||||||||||
 Components | Putative cytochrome P450 hydroxylase | ||||||||||||
 Keywords |  OXIDOREDUCTASE / Cytochrome P450 / peptide cyclase / NRPS-associated / glycopeptide antibiotic | ||||||||||||
| Function / hom*ology |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen /
PROTOPORPHYRIN IX CONTAINING FE / Putative cytochrome P450 hydroxylase | ||||||||||||
| Biological species |  Actinomadura parvosata subsp. kistnae (bacteria) | ||||||||||||
| Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.001 Å | ||||||||||||
 Authors | Greule, A. / Izore, T. / Cryle, M.J. | ||||||||||||
| Funding support |  Australia,  Germany, 3items
| ||||||||||||
 Citation | Journal: Front Chem / Year: 2022 Title: The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage. Authors: Greule, A. / Izore, T. / Machell, D. / Hansen, M.H. / Schoppet, M. / De Voss, J.J. / Charkoudian, L.K. / Schittenhelm, R.B. / Harmer, J.R. / Cryle, M.J. | ||||||||||||
| History |
|
| Deposited unit | A: Putative cytochrome P450 hydroxylase hetero molecules
| ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
| ||||||||||||||||
| Unit cell |
|
| #1: Protein | Mass: 42379.688 Da / Num. of mol.: 1
|
|---|---|
| #2: Chemical | ChemComp-GOL / Glycerol
Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C3H8O3
|
| #3: Chemical | ChemComp-HEM / Heme B
Mass: 616.487 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C34H32FeN4O4 / Feature type: SUBJECT OF INVESTIGATION
|
| #4: Water | ChemComp-HOH / Water Mass: 18.015 Da / Num. of mol.: 229 / Source method: isolated from a natural source / Formula: H2O
|
| Has ligand of interest | Y |
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